); Ea. Naphthenic solvents are clearly the best choices for replacing xylene and other aromatic solvents. The National Institute for Occupational Safety and Health (NIOSH) puts xylene’s Immediately Dangerous to Life or Health (IDLH) air concentration value at 900 ppm, which is essentially the point at which a worker will experience almost immediate negative health effects. If you need to slowly dry paint, xylene solvent can even be used as a substitute for toluene. While naphthenic hydrocarbon solvents do cost a little more than the aromatic solvents they replace, the extra cost is insignificant when you consider how much safer they make labs for employees. Research conducted by CBG Founder and Chairman, Gerald W. Camiener, Ph.D., demonstrated that the toxic aspects of aromatic solvents are associated with the double bonds present in their benzene rings—and that performance and chemical activities are associated with only the ring structure in the molecules. Neo-Clear® is an aliphatic hydrocarbon mixture that can substitute the same applications as xylene in the histo-medical lab - histoprocessing, deparaffination and clearing after dehydration in staining process It is not necessary to change methods or incubation times when using Neo-Clear® instead of xylene. Related Products: Xylene Histological Complete Dye Sets. Dry Stains & Dyes. Xylene will also remove certain adhesives, and is an excellent solvent for cleaning tools and equipment immediately after use. Oak Ridge: Xylene is well known as an excellent solvent â often used in the printing, paint, rubber and leather industries since it has high solvency power, as demonstrated by its high Kauri-Butanol (K-B) Value of 98. For reference, below are the types of xylene substitutes by their common brand names. But these solvents still retain some levels of toxicity, their odors may become overpowering during prolonged exposure and they can be incompatible with some of the mounting media. May 25, 2018 / by CitriSolv⢠provides for better tissue sections - it will not harden or shrink tissue. Vapors can be irritating to mucous membranes, hazardous in case of skin contact, slightly hazardous in case of ingestion. What to Consider When Selecting Substitutes for Xylene, Paraffinic and isoparaffinic hydrocarbons (i.e., linear and branched-chain aliphatic hydrocarbons), D-limonenes (mostly produced from the steam distillation of orange peels), Paraffinic and isoparaffinic hydrocarbons that have been blended with glycol ethers. To eliminate the use of xylene, the present study was designed with eco-friendly materials which are nontoxic, less hazardous and economical. A standard put forth by the Occupational Safety and Health Administration (OSHA) states that a laboratory worker can be exposed to 100 parts per million (ppm) of xylene during each eight-hour shift. Reprotoxicology Reagents. 237ml (8oz) Bottles. Clear-Rite 3, produced by Richard-Allan, is similar to Pro-Par Clearant in that it has the same evaporation rate, penetration rate and drying time of xylene. For xylene the contaminants are mostly alcohol, biological materials and paraffin. Toluene and Xylene. Today, histology, pathology, cytology, research, veterinary, parasitology and dermatopathology labs should work to provide a safe environment for personnel by helping them avoid the toxic and dangerous effects of xylene. Chemically, these newer, safer solvents are naphthenic hydrocarbons. Xylene, also referred to as xylol, is any of three different isomeric liquid substances used as a solvent in the manufacture of dyes, resins, insecticides, fuels, perfumes and films. Sub-X is an economical xylene substitute that is an essentially odorless and nongreasy aliphatic hydrocarbon. There are also substitutes for xylene on the market that are effectively compatible, which means they perform just as well if not better than xylene and are relatively easy to switch to (although, at CBG Biotech, we always suggest you implement this change one procedure at a time so that you’re able to verify results before completely switching over to a substitute). Dry Stains & Dyes. Epredia⢠Xylene Product ID: clearene-solvent Clearene is a selected blend of terpenes formulated specifically to replace xylene and toluene in histology and cytology laboratory procedures. This is why itâs commonly used as a thinning agent. Microbiology Staining Solutions (Ready to use) Haematology Stains. Miscellaneous. Dextromethorphan relieves cough by suppressing the cough reflex in the brain 3 4. Now, xylene is also illegal to purchase in California due to carcinogen reasons, and has been replaced on the shelf with a "toluene substitute" that uses a mix of various chemicals with small amounts of xylene. An almost odourless formula with low toxicity levels, Clear-Advantage is another xylene substitute available from Polysciences, Inc. (see Resources). The poorest-performing substitutes for xylene are the paraffinic and isoparaffinic hydrocarbons and the mixtures of paraffinic hydrocarbons with glycol ethers. As a nonpolar mixture, xylene solvent is also excellent at dissolving nonpolar substances such as paints and varnishes. Their higher boiling points make it easier to separate from the contaminants. I don't know anything about the product 'Clarify', but in the United States I am aware of a couple of 'xylene substitute' solvents offered by CBG ⦠Non-Hazardous Alternatives for Toluene . Procedures in histology, cytology, pathology, microbiology, hematology and gutta purcha that use toxic reagents such as xylene, carbol-xylene, ethyl acetate and formalin can substitute Hemo-De in their procedures. Options . Acetone is a smaller molecule than xylene and it contains an oxygen atom in the molecular structure. Twenty of the 30 substitutes for xylene on the market today are safer than using xylene itself. Figures in the table less than 1.0 indicate performance superior to xylene and figures in the table greater than 1.0 indicate performance inferior to xylene. Westerfield is a certified Hatha yoga instructor and a Whole Foods Nutrition Counselor with a focus in macrobiotics and traditional Eastern healing arts. The xylene and ethanol baths used during tissue processing are discarded and replaced with fresh solvent on a weekly basis. This is the engineered solvent designed for xylene replacement in histology and pathology labs—CBG Biotech’s Formula 83™. Dextromethorphan Hydrobromide Dextromethorphan is an opioid typed analgesic and anti-trussive agent used to relieve coughs due to colds or flu, but not chronic coughs that occur with smoking, asthma or emphysema 3 4. Mr. Camiener is President of CBG Biotech, Ltd., Co., a manufacturer and supplier of recycling equipment to the laboratory, hospital and industrial markets. Her interests include food, culture, holistic health, yoga and literature.
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