Registrants can choose from the following picklist endpoint conclusions: If an adverse effect is observed, data can be provided as LD 50 or discriminating dose, displayed here in milligrams per kilogram bodyweight. Autoflammability / Self-ignition at 101 325 Pa provides substance information on the substance’s self-ignition temperature in °C at a pressure of 101 325 Pa. Bioaccumulation Factor (aquatic species) L/kg ww provides substance information on the substance’s bioaccumulative properties for aquatic species measured in litre per kilogram (wet weight). For readability purposes, only the pictograms, signal words and hazard statements referred to in more than 5% of the notifications under CLP are displayed. 0.25M solution of pyridinium chloride was found to have a pH of 2.699. Registrants can register their substance’s flammability as: This section summarises the explosiveness values from all registered dossiers for the substance. This section summarises the values related to toxicity to soil macroorganisms (except arthropods) from all registered dossiers for the substance. H atm m3/mol provides substance information on the substance’s Henry’s Law Constant in atm m3/mol at a temperature measured in °C and a pressure measured in Pascal. LC50 for marine water invertebrates provides substance information on the substance’s lethal concentration for 50% of the marine water invertebrates in the test, displayed in milligram per litre. ECHA has no public registered data indicating whether or into which articles the substance might have been processed. Data is generally displayed in milligram per kilo bodyweight. For other data an order of magnitude logic might apply; e.g. These substances cannot be placed on the market or used after a given date, unless an authorisation is granted for their specific use, or the use is exempted from authorisation. the electronic edition of the Official Journal of the European Union.This Brief Profile is covered by the ECHA Legal Notice. If more than one numerical result is available per endpoint, the range of results (min-max) and range of experimental conditions will be presented (RANGE method). Please see the endpoint help sections for more specific information on the sections or see the ‘Scientific properties’ header for a more complete overview. Values are generally displayed in milligram per kilo soil (dry weight). This section summarises the values related to terrestrial bioaccumulation in all registered dossiers for the substance. Cetylpyridinium chloride is a cationic quaternary ammonium compound used as oropharyngeal antiseptic. CAS names gives the name(s) provided to ECHA by the Chemical Abstracts Service, a division of the American Chemical Society, where available. Alpha proton of ester pKa = 25 12. The information provided in the free-text fields is not published in the Brief Profiles. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Registrants can choose from the following (picklist) conclusions: Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as above. Half-life in sediment provides substance information on the substance’s half-life in sediment in seconds/minutes/hours/days/weeks/months/years at a temperature measured in °C.Note: Results without a measurement condition (temperature) are not processed for the Brief Profile. EC50/LC50 for marine sediment provides substance information on the substance’s effect concentration or lethal concentration for 50% of the model organisms feeding off the marine sediment, generally displayed in milligrams per kilogram (dry weight). See information under ‘Study results oral’. The data presented in these sections has been cleaned to remove names of one character or less, or names which consist solely of punctuation or numerical characters. The EC Inventory is a combination of three independent European lists of substances from the previous EU chemicals regulatory frameworks (EINECS, ELINCS and the NLP-list). 3. See ‘Data for workers – Inhalation exposure’, with the following additional hazard assessment conclusion in the case of short term: The registered threshold is generally displayed in milligrams per kilogram per bodyweight per day. The Agency thus cannot guarantee the correctness of the information displayed. Hazard for predators provides information on the substance’s hazard assessment conclusion related to predators/secondary poisoning. Pyridinium, 1-hexadecyl- chloride. This section summarises the values related to toxicity to (terrestrial) plants from all registered dossiers for the substance. This section displays the values related to acute toxicity from all registered dossiers for the substance. For temperature for example, data is standardised and displayed in Celsius (°C). Other relevant information includes the following: To see the full list of notified classifications and have more information on impurities and additives relevant to classification, you can consult the C&L Inventory. This section summarises the values related to phototransformation in air from all registered dossiers for the substance. the lowest numerical data) is displayed. Hazard for terrestrial organisms provides information on the substance’s hazard assessment conclusion related to terrestrial organisms/soil. Note: Registrants can also select ‘other’ as a reaction type for the degradation rate constant of the substance. 0000006099 00000 n Displayed is the MOST CONSERVATIVE of the value(s) provided, ranking in the order as below. The Index number is the identification code given to substances in Part 3 of Annex VI to the CLP Regulation ((EC) No 1272/2008). If this number is wrong then it means that pyridine may have quite a typical pKa ⦠Additionally, if available, information on the use of the substance and how consumers and workers are likely to be exposed to it can also be displayed here. Alcohol pKa = 16‐18 8. Otherwise data is displayed reported as provided by the registrant(s).The availability of additional data beyond the five results displayed is indicated by (…). Fusce eget lorem sed purus tempus blandit. This section provides information on the recommended measures to minimise or prevent adverse effects resulting from exposure to a hazardous product, or improper storage or handling of a hazardous product. 1. Synthesis and in vitro kinetic evaluation of N-thiazolylacetamide monoquaternary pyridinium oximes as reactivators of sarin, O-ethylsarin and VX inhibited human acetylcholinesterase (hAChE) Bioorganic & Medicinal Chemistry, 2015. Values are generally displayed in milligram per litre. This section summarises the values related to toxicity to birds from all registered dossiers for the substance. trailer The results of matching substance classifications are displayed in percentages of the total number of notifications. When more than one summary is provided, DN(M)EL values may refer to constituents of the substance and not to the substance as a whole. For a detailed overview on identified uses and environmental releases, please consult the detailed information from the registration dossiers. If in eyes: rinse cautiously with water for several minutes. Additionally, its product categories are Heterocyclic Compounds; Pyridinium ⦠Information in the guidance on safe use section consists of recommendations by a substance registrant(s) on the proper use of the substance in various situations. Registrants can report substance information on viscosity as: Static viscosity at 20°C provides substance information on the substance’s (static) viscosity per square millimetre per second at a temperature of 20°C. This substance is used for the manufacture of: chemicals. Suppliers, 15 BASF, 10 Gangwal Chemicals, 10 Roquette, 10 Seppic, 4 Nanjing Bold Chemical, 3 SPI Pharma, 3 Corel Pharma Chem, 2 Zhejiang Huakang Pharmaceutical, 2 Finar, 1 Capsugel, 1 Rochem International Inc, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Aeon Procare, 1 Vasa Pharmachem, 1 Ideal Cures Pvt … The pyridinium is a great leaving group pKa Conjugate Acid 9.7-2.4 Nuc leophi M ayrv 13.2 7.5 DMAP EtOH. This section summarises the flammability values from all registered dossiers for the substance. 0000001961 00000 n The pyridinium is a great leaving group O R'OR. List of substances proposed as POPs - Indicates if the substance has been proposed for its inclusion in the Stockholm Convention or if a proposal is under preparation in the European Union. If you have any comments or suggestions, please contact ECHA using our contact form. Koc provides substance information on the substance’s Koc adsorption at a temperature measured in °C and a percentage of organic carbon. ABC corresponds to the atomic number of the most characteristic element or the most characteristic organic group in the molecule. 0000003077 00000 n This section summarises the values related to adsorption/desorption from all registered dossiers for the substance. Cetilpiridinijev klorid (hr) Biocidal active substances . Koc at 20°C provides substance information on the substance’s Koc adsorption at a temperature 20 °C. Melting / freezing point provides substance information on the melting/freezing point in °C at a pressure measured in Pa. Note: Registrants can also select ‘other’ as the unit of measure for pressure. For strengths of organic acids see E. P. Serjeant and B. Dempsey (eds. Duis pulvinar non magna ac viverra. The quality and correctness of the information remains the responsibility of the data submitter. Active substance approval – indicates if the substance is an approved biocidal active substance. Applicant’s summary and conclusion – Interpretation of results. The date of the last update corresponds to the publication date of the Brief Profile and not necessarily to the date in which the update occurred in the source data (registered dossiers, the C&L Inventory or a regulatory process). For sections such as substance use, chemical properties and the classification and labelling of substances, the quantity and quality of the information is the responsibility of manufacturers and importers. AI3-30571. EC10 / LC10 or NOEC for marine water plants provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested marine water plants or the no observed effect concentration for marine water plants. Note: Registrants can also select ‘other’ as the type of Henry’s law constant. Values are generally displayed in measured in (nano/ micro/milli)gram per kilogram (dry weight). While it is present in the final substance, it was not intentionally added. Vivamus mauris lorem, fringilla at diam a, laoreet consequat eros. RST is the consecutive number of the substance in the series ABC. Study results are not processed for carcinogenicity in the context of Brief Profiles due to the use of complex field(s) to report the information, which cannot be easily summarised by an automatic algorithm. Data is generally standardised and displayed in in milligram per kilo of food. This section displays the values related to genetic toxicity from all registered dossiers for the substance. Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Cetylpyridinium chloride (CPC) is a cationic quaternary ammonium compound used in some types of mouthwashes, toothpastes, lozenges, throat sprays, breath sprays, and nasal sprays. This section displays the values (see below) related to toxicokinetics, metabolism, and distribution from all registered dossiers for the substance. stemming. As you already know, the chloride ⦠0000002363 00000 n REACH registration dossiers notifications. Long-term EC10 or LC10 or NOEC for birds provides substance information on the substance’s effect concentration or lethal concentration (long term) for 10% of the birds in the test, or the no observed effect concentration for birds. <]>> If more than one IUPAC name is available from REACH registered dossiers, all IUPAC names are displayed in ‘Other names’ section of the Brief Profile. Kb for pyradine is 1.7x10E-9? To a stirred solution of pyridine-2-carbonitrile (0.01 mol) in DMSO (3.0 mL), cooled in an ice bath, was added 30% hydrogen ⦠To confirm if a substance is covered by a specific legislative framework the official publication should be consulted.Reproduction or further distribution of this information may be subject to copyright protection. Short-term EC50 or LC50 for soil dwelling arthropods provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the soil dwelling arthropods in the test, generally displayed in milligram per kilo soil (dry weight). Displayed are the RANGES of min – max of the PRIORITISED value(s) within the five highest priority groupings of provided data. Values are generally displayed in milligrams per kilogram (dry weight). The quality and correctness of the information remains the responsibility of the data submitter. EC10 / LC10 or NOEC for marine sediment provides substance information on the substance’s effect concentration/lethal concentration for 10% of the model organisms feeding off the marine sediment or the no observed effect concentration for of the model organisms feeding off the marine sediment. See ‘Summary oral systemic effects’, except: ‘See Summary inhalation systemic effects’. Short-term EC50 or LC50 for terrestrial plants provides substance information on the substance’s effect concentration or lethal concentration (short term) for 50% of the terrestrial plants in the test, generally displayed in milligram per kilo soil (dry weight). Applicant’s summary and conclusion – Interpretation of results (inhalation). Note that this does not mean that they are properly structured names according to the IUPAC nomenclature. EC10 / LC10 or NOEC for freshwater invertebrates provides substance information on the substance’s effect concentration/lethal concentration for 10% of the tested freshwater invertebrates or the no observed effect concentration for freshwater invertebrates. See information under ‘Applicant’s summary and conclusion – interpretation of results (oral)’.
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